Kamagra 50, which contains sildenafil citrate as its active ingredient, is generally safe and well-tolerated when used as directed. However, like any medication, it may have potential side effects, both short-term and long-term. Here's an overview of Kamagra 50's potential long-term side effects:

Cardiovascular Effects: Long-term use of Kamagra 50 mg may potentially affect cardiovascular health, especially in individuals with pre-existing heart conditions. Sildenafil, the active ingredient, can cause a temporary decrease in blood pressure, and in rare cases, it may lead to serious cardiovascular events such as heart attack or stroke. This risk is higher in individuals with heart disease, hypertension, or those taking certain medications (like nitrates) that interact with sildenafil.

Vision Changes: Some users of sildenafil-based medications have reported visual disturbances, such as changes in color vision, blurred vision, or sensitivity to light. While these effects are usually temporary and resolve on their own, long-term use may potentially lead to more persistent visual issues in rare cases.

Hearing Loss: There have been rare reports of sudden hearing loss associated with the use of PDE5 inhibitors like sildenafil. While the exact mechanism is not fully understood, it's essential to be aware of this potential risk, especially with prolonged use.

Priapism: Priapism is a rare but serious side effect of sildenafil and other PDE5 inhibitors. It is a prolonged and painful erection lasting more than four hours and requires immediate medical attention to prevent tissue damage to the penis. Long-term use of sildenafil may increase the risk of priapism, especially in individuals predisposed to this condition.

Tolerance and Dependency: With long-term use, some individuals may develop a tolerance to the effects of sildenafil, requiring higher doses for the same efficacy. Additionally, psychological dependency on the medication for sexual performance may occur in some cases.